Department of Oncology, University College London Cancer Institute, London, UK; University College London Hospitals NHS Foundation Trust, London, UK. Cancer Research UK & UCL Cancer Trials Centre, University College London Cancer Institute, London, UK. Medical Oncology Department, Istituto Europeo di Oncologia, Milan, Italy. Medical Oncology Department, Hospital Universitario Málaga General FIMABIS, Málaga, Spain. Medical Oncology Department, University Hospital Ramón y Cajal, Madrid, Spain. Medical Oncology Department, Christie Hospital NHS Foundation Trust, Manchester, UK. Department of Pulmonology, Maastricht University Medical Center, Maastricht, The Netherlands. University College London Hospitals NHS Foundation Trust, London, UK. Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany. Boehringer Ingelheim B.V., Alkmaar, The Netherlands. Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany; Institute of Pharmacology, University of Mainz, Mainz, Germany. Department of Oncology, University College London Cancer Institute, London, UK; University College London Hospitals NHS Foundation Trust, London, UK. Electronic address: smlee@ucl.ac.uk.